§02 Research · the work
Publications,
posters,
and the science.
§02 All work
Culturing CAR-T cells under hypoxic and hyperbaric conditions yields increased proliferation and functional potency without changes in phenotype.
ISCT Annual Meeting · New Orleans, LA
Modulating Environmental Conditions to Enhance Production of Potent Cell Therapies for the Solid Tumor Microenvironment.
ISCT Annual Meeting · Vancouver, Canada
[2024]
CD19 CAR T manufactured under TME culture conditions exhibit superior potency & persistence.
Xcell Biosciences
app note
[2021]
Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
Clin Cancer Res.
publication
[2017]
Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysis.
Blood.
publication
[2015]
Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397.
Cancer Discov.
publication
[2012]
Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers.
J Biol Chem.
publication